A study from Agharkar Research Institute, Pune has found that a protein called cellular communication network factor 2a (Ccn2a) secreted from intervertebral disc cells induces disc regeneration in aged degenerated discs by promoting cell proliferation and cell survival.
New Delhi: Pune-based scientists have found that a protein in zebrafish that helps in disc maintenance and promotes regeneration in aged discs among the vertebrae has a similar effect on the degenerated human discs, the Ministry of Science and Technology said in a statement. may have potential therapeutic implications.
In humans, discs naturally degenerate, causing a number of related health concerns including low back, neck and appendicular pain. Currently, only symptomatic treatments are available for disc degeneration, which include pain relievers or anti-inflammatory drugs.
Disc replacement or disc fusion surgery is performed in severe cases.
There is an urgent need to develop a treatment to suppress disc degeneration or promote disc regeneration in humans.
Medical examinations have provided insight into the stages of human disc degeneration, but limited information is available regarding the cellular and molecular processes that play a role in disc maintenance. Most importantly, there is no medical procedure or treatment known to suppress disc degeneration or induce disc regeneration.
A study conducted by the Agarkar Research Institute (ARI), Pune, an autonomous institute of the Department of Science and Technology, revealed that a protein called cellular communication network factor 2A (CCN2A) secreted by intervertebral disc cells stimulates disc regeneration in chronic degenerated discs. Encourages and inspires. Cell proliferation and cell survival by modulating a pathway called the FGFR1-SHH (fibroblast growth factor receptor-sonic hedgehog) pathway.
The study using zebrafish as a model organism is the first in vivo study showing that it is possible to induce disc regeneration in a degenerated disc by activating endogenous signaling cascades.
The scientists also found that the Ccn2a-FGFR1-SHH signaling cascade plays a positive role in disc maintenance and enhancing disc regeneration.
The study, published in the journal Development, used genetic and biochemical approaches and may help design a new strategy to suppress disc degeneration or induce disc regeneration in degenerated human discs.
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